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KMID : 0363220110490090822
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Korean Journal of Dermatology
2011 Volume.49 No. 9 p.822 ~ p.825
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Nonpigmenting Fixed Drug Eruption due to Codeine
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Choi Yun-Seok
Lim Won-Suk
Jin Sang-Yun
Lee Joon-Ho
Lee Seung-Ho
Lee Ai-Young
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Abstract
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Fixed drug eruption is a distinctive and clinically recognizable entity that is characterized by well-demarcated erythematous plaques recurring in exactly the same sites as on previous occasions. Unlike the pigmenting form of fixed drug eruption, nonpigmenting fixed drug eruption leaves no pigmentation when it resolves. We now report the case of a 44-year-old man who presented with diffuse ill-defined erythematous patches on both hands, feet and lower legs with a burning sensation, which is considered an atypical manifestation for fixed drug eruption. The patient had a history of similar skin lesions developing after medications on the corresponding regions. The patch test with suspected drugs showed negative reactions on both lesions and unaffected sites. The lesions were reproduced on the oral provocation test with codeine and resolved without pigmentation. The patient was diagnosed with nonpigmenting fixed drug eruption due to codeine.
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KEYWORD
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Atypical manifestation, Codeine, Nonpigmenting fixed drug eruption, Provocation test
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